Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age이중 가닥 RNA는 dsRNA 길이, IFNAR1 발현 및 연령에 따라 항바이러스성 선천성 면역 반응, 질병 행동 및 인지 기능 장애를 유발합니다.Article Published on 2021-07-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 치료법, [키워드] age age-dependent effect age-dependent effects Alzheimer's disease Analysis Anti-viral autism base binding Brain circulating CNS cognitive Cognitive function COVID19 cytokine Cytokines dependent on disease dose dsRNA dysfunction expression Gene Expression IFN-I IFNAR1 Ifnb IFNβ IL-1β IL-6 immune activation immune responses Impact implication Inflammation innate immune response innate immune responses Innate immunity integrity IRF7 memory mice molecular weight neurodegenerative disorder neurodegenerative disorders Neuroinflammation overcome parkinson s disease Parkinson's Disease plasma Poly I:C produced Psychiatric question response responses RNA robust SARS-CoV-2 Schizophrenia Sickness Sickness behaviour significantly Symptom systemic systemic inflammation TNF-α Transcription triggered type I interferon type I interferon. viral infection viral replication Working memory [DOI] 10.1016/j.bbi.2021.04.016 PMC 바로가기 [Article Type] Article
Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigsArticle Published on 2014-11-282023-06-23 Journal: Vaccine [Category] 신종인플루엔자, [키워드] Inactivated swine influenza vaccines Poly I:C swine influenza virus Vaccine adjuvants [DOI] 10.1016/j.vaccine.2014.11.034 PMC 바로가기 [Article Type] Article
Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infectionOriginal Article Published on 2013-08-052023-06-14 Journal: Acta pharmacologica Sinica [Category] Fulltext, 신종인플루엔자, [키워드] Antiviral agents Arbidol Cytokines Influenza Macrophage oseltamivir Poly I:C [DOI] 10.1038/aps.2013.54 PMC 바로가기 [Article Type] Original Article
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article